| 简介 |
The object of the present invention is to provide a method for efficiently and industrially deuterating a haloacrylic acid or salt thereof. The present invention is an invention of a deuteration method of a compound represented by the general formula [1] : wherein, R 1 and R 2 indicate each independently a light hydrogen atom or a heavy hydrogen atom and at least one of R 1 and R 2 indicates a light hydrogen atom; R 3 indicates a light hydrogen atom, a heavy hydrogen atom, an alkaline metal atom or an alkaline earth metal atom; X indicates a halogen atom; and n indicates 1 or 2, which comprises reacting the compound represented by the general formula [1] with a heavy hydrogen source in the presence of a catalyst selected from a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst that are not subjected to activation processing; and an invention of a deuterated compound represented by the general formula [2] : wherein, R 4 and R 5 indicate each independently a light hydrogen atom or a heavy hydrogen atom and at least one of R 4 and R 5 indicates a heavy hydrogen atom; R 3 indicates a light hydrogen atom, a heavy hydrogen atom, an alkaline metal atom or an alkaline earth metal atom; X indicates a halogen atom; and n indicates 1 or 2. |
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