| 简介 |
PURPOSE : Provided are a polysuccinimide-based polymer which is excellent in the size control of polymer particles, biodegradability and contrast effect, and a contrast agent containing the polysuccinimide-based polymer.
CONSTITUTION : The polysuccinimide-based polymer is represented by the formula 1, wherein R1 is a hydrophilic group having a molecular weight of 100-20, 000 derived from D-lysine, L-lysine, D, L-lysine, polylysine, polyethylene glycol, poly(vinyl pyrrolidone), dextran, polyethylene oxide or poly(vinyl alcohol); and R2 is a chelating group where a contrast agent selected from gadolinium, manganese, iron oxide, aluminum, silicon, barium, yttrium and rare earth elements is trapped.
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