| 简介 |
PURPOSE : Provided are a polysuccinimide-based polymer which shows excellent polymer particle size control, biodegradability and contrast effect when nanoparticles are formed, and a contrast agent containing the polymer.
CONSTITUTION : The polysuccinimide-based polymer comprises a main chain having a molecular weight of 1, 000-100, 000; and a side chain which comprises a hydrophilic group having a molecular weight of 100-20, 000 derived from D-lysine, L-lysine, D, L-lysine, polylysine, polyethylene glycol, poly(vinyl pyrrolidone), dextran, polyethylene oxide or poly(vinyl alcohol), a hydrophobic group derived from a C3-C80 amine or phospholipid, and a chelating group where a contrast agent selected from gadolinium, manganese, iron oxide, aluminum, silicon, barium, yttrium and rare earth elements is trapped.
© KIPO 2007 |
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