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TOLERANCE-INDUCED TARGETED ANTIBODY PRODUCTION 检索报告

2023-12-21 3760 35K 0

专利信息

申请日期 2025-06-25 申请号 WOUS04002562
公开(公告)号 WO2004067553A3 公开(公告)日 2006-08-17
公开国别 WO 申请人省市代码 全国
申请人 THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK; MICHL Josef; BRADU Stefan M
简介 The present invention provides methods for directing the immune response of an animal towards immunologically weak or rare antigens such as tumor antigens. The methods combine subtractive immunization with hyperimmunization and result in the controlled or directed production of target-specific antibodies, helper T cells (CD4+-T lymphocytes) and cytotoxic T cells (CD8+-T lymphocytes). Also provided by the present invention are untransformed and transformed cell lines, and growth media necessary to grow the untransformed cell line in a differentiated state. Monoclonal antibodies which react with different neoplastic cell lines and hybridomas producing such antibodies are also provided.


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