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FLEXIBLE VACCINE ASSEMBLY AND VACCINE DELIVERY PLATFORM 发明申请

2023-10-19 4520 5757K 0

专利信息

申请日期 2025-07-12 申请号 WOUS05010191
公开(公告)号 WO2005091753A2 公开(公告)日 2005-10-06
公开国别 WO 申请人省市代码 全国
申请人 LARGE SCALE BIOLOGY CORPORATION
简介 Herein described are various methods for making a vaccine that are made of re­assembled virus like particles (VLP). First, the VLPs are disassembled into coat proteins or encapsidation intermediate populations. Each population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different coat proteins or encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different coat proteins such that the reassembled VLP displays more than one peptide or other molecule. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.


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