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FLEXIBLE VACCINE ASSEMBLY AND VACCINE DELIVERY PLATFORM 检索报告

2023-10-03 1760 174K 0

专利信息

申请日期 2025-07-11 申请号 WOUS03018247
公开(公告)号 WO03103605A3 公开(公告)日 2005-03-31
公开国别 WO 申请人省市代码 全国
申请人 LARGE SCALE BIOLOGY CORPORATION
简介 Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.


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