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A method and a precursor for the large-scale production of upconverting nanocrystals derived from a NaYF4 host are provided. A rare earth based precursor is combined with a hydrophobic fluoride precursor, which is based upon a long-chain n-alkyl amine to form a reaction solution. The reaction solution is heated under an inert gas to temperatures above 300° C., whereby upconverting NaYF4-based nanocrystals are nucleated and grown.