PEPTIDE FOR ANTI-EBOLA VACCINE

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Based on the concept according to which protein immunogenicity more likely resides in unique/rare peptide sequences and aiming at defining epitopic peptides that might serve for therapeutic anti-Ebolavirus (EV) vaccines, a set of 45 EV proteomes was searched for peptide motifs unique to EVs and absent in human proteins. The search highlighted one peptide, LWQQWDR, that represent the molecular signature of the 45 EVs and is absent in the human proteome at the pentapeptide level. Synthetic oligopeptide constructs based on such unique viral fragment might be used for constructing synthetic oligopeptides for vaccine formulations, thus offering the possibility of hitting 1) multiple EV species/strains, 2) with high specificity and 3) without crossreactivity-associated adverse events. A rationale for constructing LWQQWDR-based synthetic oligopeptides is also described.