RARE EARTH-BASED NANOPARTICLE MAGNETIC RESONANCE CONTRAST AGENT AND PREPARATION METHOD THEREOF

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A rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof. The rare earth-based nanoparticle magnetic resonance contrast agent are rare earth-based inorganic nanoparticles having the surface coated with a hydrophilic ligand, which is prepared by the following method : firstly rare earth-based nanoparticles are obtained by a high-temperature oil phase reaction, and then the surface is coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with the existing clinical contrast agent, the magnetic resonance contrast agent has a greatly improved relaxation rate, a good imaging effect, a low injection dose as required, and a relatively long time in a body. In addition, a rigid structure of the inorganic nanoparticles can effectively reduce the free possibility of gadolinium ions.