Examination methods of the bio-marker of allele

文件类型：PDF文档
文件大小：1258K
According to the present invention, in order to enhance biomarker searching and discovering power, continuous variables used when defining nucleotide polymorphism are used to select and rank disease variation markers based on comparison analysis methods (allele square value difference, allele depth tangent difference, allele absolute value difference, geometric allele difference, statistical allele difference, and allele imbalance proportion), the weighted value with respect to the locus function, or the like, followed by reverse classification, thereby improving the sensitivity of discovering genome biomarkers corresponding various cancers, drug resistance of cancers, rare diseases, chronic diseases, and disease risks and phenotypes of normal persons, when compared with existing methods.(DD) Cancers (paired samples)(EE) Personal genome for health care(FF) Worldwide genome related corporation, institution, and center generation raw data(GG) Processed general / disease average / profile information(HH) Well-arranged personal disease information report(CC) Rare diseases, Chronic diseases(BB) Genome data for research/prediction(AA) Personal genome disease allele mutation finding and searching schemaCOPYRIGHT KIPO 2015