SUBSTITUTED AZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING DISEASES, DISOR

文件类型：PDF文档
文件大小：4941K
FIELD : medicine, pharmaceutics.SUBSTANCE : present invention refers to organic chemistry, namely azepine derivatives of general formula(I) or pharmaceutically acceptable salts thereof, wherein X represents S; Rand Rare independently specified in a group of substitutes consisting of H, halogen, C-alkyl, C-alkylphenyl, C-alkenyl, OR, CON(R), SON(R), phenyl, if necessary containing up to three substitutes of Calkyl, halogen or Calkoxy-groups; Ris specified in a group consisting of H, C-alkyl, OR; Rrepresents H, or Rand Rtogether represent a five-merous saturated cycle; Ris specified in a group consisting of H, C-alkyl; Rrepresents H, or Rand Rtogether represent the substitute -CHCH-; Ris specified in a group consisting of C-alkyl, or Rtogether with the atom whereto attached represents pyrrolidinyl; or Rrepresents 4-trifluoromethoxyphenyl or 2-trifluoromethylphenyl, then X represents S, and R, R, R, Rand Rrepresents hydrogen, provided a derivative is other than 8- phenyl-5, 6, 7, 8-tetrahydro-4H-thieno[2, 3-d]azepin-3-ol and 2-bromo-8-phenyl-5, 6, 7, 8-tetrahydro-4H-thieno[2, 3-d]azepine-3-ol. Also, the invention refers to a pharmaceutical composition of the compounds of formula (I) and a method treating disorders on the basis of the use of the compound of formula (I).EFFECT : there are produced new azepine derivatives effective in 5HT-receptor function modulation.6 cl, 1 tbl, 49 ex