PHOSPHONIC ACID DERIVATIVES AND USE THEREOF AS P2Y12 RECEPTOR ANTAGONISTS

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FIELD : medicine, pharmaceutics.SUBSTANCE : invention refers to derivatives of Ice formula and the use thereof in treating the diseases associated with thrombocyte aggregationI, wherein P(O)RRis specified inRis specified in phenyl; W is specified in a bond, -O-, -NR-; Ris specified in alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, phenyl, heterocyclyl, or heteroaryl, alkoxycarbonyl alkyl, carboxyalkyl or phenyl alkyl; Ris specified in hydrogen or alkyl; or Rand Rform a ring together with a nitrogen atom; Ris specified in hydrogen or methyl; Ris specified in alkoxy; n is from 0 to 3; m is from 0 to 1; V is specified in a bond and phenyl; Rand Rare specified in hydroxyl, phenyloxy, benzyloxy, -O-(CHR)-O-C(=O)-R, -O-(CHR)-O-C(=O)-O-R, -O-(CHR)-C(=O)-O-R, -NH-(CHR)-C(=O)-O-R, -NH-C(CH)-C(=O)-O-R; q is equal to 2; Ris specified in hydrogen and alkyl; Ris specified in alkyl or cycloalkyl; Ris specified in alkyl; Ris specified in hydrogen, alkyl, phenyl or benzyl; and Ris specified in hydrogen, alkyl or alkoxy.EFFECT : new P2Y12 receptor antagonists are produced.25 cl, 126 ex, 5 tbl