ALKYNYL-PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

文件类型：PDF文档
文件大小：21831K
FIELD : chemistry.SUBSTANCE : invention relates to novel alkynyl-phenyl derivatives which are inhibitors of isomerase activity in the visual cycle in case of ophthalmic diseases or disorders. In formula (A) : , m equals 0 or 1; Z is -C(R)(R)-C(R)(R)- or -C(R)(R)-C(R)(R)-C(R)(R)-; Y is a bond, -C(R)(R)- or -C(R)(R)-C(R)(R)-; Rand Rare each independently selected from hydrogen, C-Calkyl or-OR; Rand Rare each independently selected from hydrogen, C-Calkyl or -OR; or Rand Rtogether form oxo; or possibly, Rand Rlocated nearby together form a direct bond while enabling formation of a double bond; Rand Rare each independently selected from hydrogen, C-Calkyl or -OR; Rand Rare each independently selected from hydrogen or C-Calkyl; each Ris identical or different from each other and independently denotes hydrogen or C-Calkyl; and each Ris identical or different from each other and independently denotes C-Calkyl, halogen or -OR; R, Rand Rare each identical or different and independently denote hydrogen, C-Calkyl or -OR; and Rindependently denotes hydrogen or C-Calkyl; values of radicals R, R, R, Rare given in the claim.EFFECT : improved method.14 cl, 14 dwg, 21 tbl, 200 ex