Yeast strain and screening method for identifying inhibitors of the expression of the hexose transpo

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(57) Abstract : The present invention provides modified yeast cell lines and their use in screening procedures for identifying in- hibitors of the expression of the hexose transporter genes by a positive phenotype. It is especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of resistance-relevant genes. The invention further provides methods for constructing said cell lines and their use in screening systems. with (an) indication(s) in relation to deposited biological For two-letter codes and other abbreviations, refer material furnished under Rule 13bis separately from the ance Notes on Codes and Abbreviations" appearing description ning of each regular issue of the PCT Gazette. with sequence listing part of description published separately in electronic form and available upon request from the International Bureau