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A method of making an earth-boring rotary drill bit includes providing a plurality of hard particles in a mold to define a particle precursor of the first region and the second region and infiltrating the panicle precursor of the first region with a molten first matrix material forming a molten first particle-matrix mixture. The method also includes infiltrating the particle precursor of the second region with a molten second matrix material forming a molten second particle-matrix mixture; and cooling the molten first particle-matrix mixture and the molten second particle-matrix mixture to solidify the first matrix material and the second matrix material and form a bit body having a first particle-matrix composite material having a first material composition in the first region and a second particle-matrix composite material having a second material composition in the second region, wherein the first particle-matrix composite material and the second particle-matrix composite material are different.