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The syringe has a re-use prevention feature where the plunger rod (26) and needle hut (38) are destroyed and the needle (64) is retracted into the rod. This feature requires only an increase of force along the same line of action as the injection stroke. This allows for safe, one-handed injection, which is critical in some situations. The syringe also minimizes the amount of wasted medication because the plunger rod tip (28) occupies the entire volume inside de the barrel (20). The retracting needle syringe uses standard luer-lok fittings and can be used with a variety of standard needles that do have rectracting cannula. A large gauge needle can be used to fill the syringe from a vial or other container before attaching the savety needle for injection. Lastly, the plunger can be completely encapsulated by the barrel prevents re-use of the syringe and allows for safe and easy disposal.