Generation of ion exchanger media

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(57) Abstract : The present invention re]ates to a method of generating a separation medium comprising mixed mode cation-exchanger ]igands coup]ed to a base matrix, which method comprises to provide a scaffo]d comprising a functiona] group and exhibit lng a cyclic core structure; derivatise the scaffold with a reagent comprising a reactive group coupled to a residue R by reacting the functional group of the scaffold with said reactive group; open the cyclic structure of the resulting derivative; and react the product with a base matrix comprising a re active group. The scaffold presents at least two functionalities; one sulphur comprising group for coupling to the base matrix and one group that can be transformed into an ionic group. Published : For two-letter codes and other abbreviations, refer to with international search report ance Notes on Codes andAbbreviations" appearing before the expiration of the time limit.for amending the ning of each regular issue of the PCT Gazette. claims and to be republished in the event of receipt of amendments