Hybrid and single chain meganucleases and use thereof

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(57) Abstract : This patent application relates to hybrid and/or single-chain rare-cutting endonucleases, called meganucleases, which recognize and cleave a specific nucleotide sequence, to polynucleotide sequences encoding for said rare-cutting endonucleases, to a vector comprising one of said polynucleotide sequences, t a cell or animal non-human comprising one of said polynucle tide sequences or said rare-cutting endonucleases, to a process for producing one of said rare-cutting endonucleases and any use of the isclosed products and methods. More particularly, this invention contemplates any use of such rare-cutting endonuclease for genetic engineering and gene therapy. European patent (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, H, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR), OAPI patent (BI B J, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published : with international search report before the expiration of the time limit for amending claims and to be republished in the event of receipt amendments For two-letter codes and other abbreviations, refer to the "Guidance Notes on Codes andAbbreviations" appearing at the beginning of each regular issue of the PCT Gazette.