Single molecule amplification and detection of DNA

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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization@ I llllIMlllllllllllllIMMllllllllllllllllllllllllllllllllllllllIMlllllllllll International Bureau (43) International Publication Date(10) International Publication Number September 2004 (30.09.2004) PCT WO 2004/083443 A1 International Patent Classilication7 : C12P 19134(74) Agents : QUINE, Jonathan, Alan et at.; Quine Intellectual Property Law Group, P.C., P.O. Box 458, Alameda, CA 945O1 (US). International Application Number : PCT/US2003/040599 (81) Designated States (national) : AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, International Filing Date : CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, 19 December 2003 (19.12.2003) GM, HR, HU, ID, IL, IN, IS, JR KE, KG, KE KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, Filing Language : English MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, Publication Language : English UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. Priority Data : (84) Designated States (regional) : AR1PO patent (BW, GH, 60/436, 098 20 December 2002 (20.12.2002) US GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW), 60/462, 384 11 April 2003 (11.04.2003) US Eurasian patent (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European patent (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, Applicant (for all designated States except US) : SI, SK, TR), OAPI patent (BF, B J, CF, CG, CI, CM, GA, CALIPER TECHNOLOGIES CORP. [US/US]; 605 GN, GQ, GW, ML, MR, NE, SN, TD, TG). Fairchild Drive, Mountain View, CA 94043 (US). Published : Inventors; and -- with international search report Inventors/Applicants (for US only) : KNAPP, Michael, -- before the expiration of the time limit for amemding the R. [US/US]; 738 Glenmere Way, Redwood City, CA 94062 claims and to be republished in the event of receipt of (US). BAKER, Jill, M. [US/US]; 660 Coleman Avenue, amendments Unit A, Menlo Park, CA 94025 (US). CHORE, Andrea [US/US]; 670 Cuesta Drive, Los Altos, CA 94024 (US). KOPF-SILL, Anne [US/US]; 30 Minoca Road, Portola Pbr two-letter codes and other abbreviations, refer to the "GuidValley, CA 94028 (US). SPAID, Michael [US/US]; 1534 ance Notes on Codes and Abbreviations" appearing at the beginErnestine, Mountain View, CA 94040 (US). ning of each regular issue of the PCT Gazette. Title : SINGLE MOLECULE AlVIPLIFICATION AND DETECTION OF DNA Abstract : Methods and systems tor pertorrning single molecule amplification for detection, quantification and statistical anal of rare nucleic acids are provided.