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Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods a re disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies m ay also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.