RARE MOLECULE SIGNAL AMPLIFICATION

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There is provided a system and method for amplifying a signal in a tyramide signal amplification (TSA) assay for detection of rare cells in a sample comprising rare cells and non-rare cells. The system and method include the use of novel blocking agents that are effective to reduce an amount of reactive tyramide binding to non-rare cells, thereby reducing background noise caused by undesired non-rare cell signal detection.