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A method of isolating a radioisotope according to example embodiments may include vaporizing a source compound containing a first isotope and a second isotope of an element, wherein the second isotope may have at least one of therapeutic and diagnostic properties when used as a radiopharmaceutical. The vaporized source compound may be ionized to form charged particles of the first and second isotopes. The charged particles may be separated to isolate the particles of the second isotope. The isolated charged particles of the second isotope may be collected with an oppositely-charged collector. Accordingly, the isolated second isotope may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.