MIXTURES OF OLIGOSACCHARIDES, WHICH ARE DERIVATIVES OF HEPARIN, METHOD OF OBTAINING THEM AND PHARM

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FIELD : chemistry. SUBSTANCE : mixtures of oligosaccharides with antithrombotic activity, with general structure of constitutive polysaccharides of heparin, have the following characteristics : average molecular weight from 1800 to 2400 Daltons, anti-Xa activity, from 190 M.units./mg to 450 M.units/mg, anti-IIa activity equals zero or practically equal to zero. Constitutive oligosaccharides of these mixtures : contain 2-16 saccharide links, have a 2-0-sulphate-4, 5-unsaturated uronic acid link on one of their ends. The mixtures contain from 30 to 60% hexasaccharide fraction, and the hexasaccharide fraction contains from 20 to 70% hexasaccharide with the following formula : in form of a salt of alkali or alkali-earth metal. A method is given of obtaining oligosaccharide mixtures and antithrombotic pharmaceutical compositions containing them, as well as a method of determining activity of oligosaccharide mixtures. EFFECT : obtaining oligosaccharides with antithrombotic activity. 28 cl, 6 ex