SYNTHETIC METHOD OF REDUCING ALKYLATING OF INDOLES IN C-3-POSITION

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FIELD : chemistry. SUBSTANCE : method lies in processing indole with aldehyde in presence of reducer - silicon hydrate, selected from group, consisting of tri(C1-C4-alkyl)sylane, triphenylsylane, diphenylsylane and phenylmethylsylane, and Lewis acid, selected from group, consisting of salts of boron, aluminium, antimony or rare-earth metal, containing halogen or triflate anion, and pentafluorophenyl metal acids, in which metal is boron, aluminium, antimony or rare-earth metal. EFFECT : elaboration of novel method of alkylating C-3-positions of indoles, applicable for indoles, which contain acid-sensitive substituents in N-1 position. 23 cl, 2 ex