Modified polyphenylenepolyamine carboxyamido radioactive complex chelating agent and coupling body

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A group of functionalized polyaminocarboxamide modified chelators, such as 1, 4 7, 10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)-7-N-(1-carboxymethyl)bis-4, 10-N, N-(carboxamidomethyl)cyclododecane and 1, 4 7, 10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)bis-4, 7-N, N-(1-carboxymethyl)-10-N-(carboxamidomethyl)cyclododecane are disclosed. These modified chelators are capable of forming complexes with rare earth-type metal ions. When the complexes are covalently attached to an antibody or antibody fragment, they can be used in therapeutic and diagnostic applications.